This best practices guide from Graphic Products describes factors you need to take into consideration when creating safety signs for your facility.

From OSHA’s perspective they have a concern about the safety sign being itself safe.  That sounds weird… that a safety sign might not be safe.  But signs can have sharp edges and bolts that protrude making them a safety hazard.

ANSI is concerned about the sign’s safety message being clearly communicated.  This means using standards ANSI has set for the different types of safety signs, as well as making the text on the sign large enough to be read from a safe distance.

This OSHA Safety Signs Best Practice guide is being offered free.  It serves as an excellent overview providing the key information you or your staff needs to make ANSI and OSHA compliant safety signs.